Aquagenic keratoderma. Two new case reports and a new hypothesis

Indian Dermatol Online J. 2014 Jan;5(1):30-3. doi: 10.4103/2229-5178.126025.


Aquagenic keratoderma has been described as a transient condition affecting predominantly young females and defined clinically by the appearance of palmar hyper-wrinkling accentuated after immersion in water. We present two new cases with aquagenic palmoplantar acrokeratoderma - a child and a young male. A significant clinical improvement was achieved after topical treatment with aluminum salts. Aquagenic palmar keratoderma may be a clue to cystic fibrosis in adolescents and young adults. We developed a new hypothesis on its pathogenesis.

Keywords: Aquagenic keratoderma; cystic fibrosis; gene association; sympathetic small fibres; treatment.

Publication types

  • Case Reports