Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 2014, 820248

MicroRNAs in the DNA Damage/Repair Network and Cancer


MicroRNAs in the DNA Damage/Repair Network and Cancer

Alessandra Tessitore et al. Int J Genomics.


Cancer is a multistep process characterized by various and different genetic lesions which cause the transformation of normal cells into tumor cells. To preserve the genomic integrity, eukaryotic cells need a complex DNA damage/repair response network of signaling pathways, involving many proteins, able to induce cell cycle arrest, apoptosis, or DNA repair. Chemotherapy and/or radiation therapy are the most commonly used therapeutic approaches to manage cancer and act mainly through the induction of DNA damage. Impairment in the DNA repair proteins, which physiologically protect cells from persistent DNA injury, can affect the efficacy of cancer therapies. Recently, increasing evidence has suggested that microRNAs take actively part in the regulation of the DNA damage/repair network. MicroRNAs are endogenous short noncoding molecules able to regulate gene expression at the post-transcriptional level. Due to their activity, microRNAs play a role in many fundamental physiological and pathological processes. In this review we report and discuss the role of microRNAs in the DNA damage/repair and cancer.

Similar articles

  • LncRNAs in DNA Damage Response and Repair in Cancer Cells
    M Su et al. Acta Biochim Biophys Sin (Shanghai) 50 (5), 433-439. PMID 29554194. - Review
    In order to maintain integrity of the genome, eukaryotic cells develop a complex DNA damage/repair response network, which can induce cell cycle arrest, apoptosis, or DNA …
  • miRNA Response to DNA Damage
    G Wan et al. Trends Biochem Sci 36 (9), 478-84. PMID 21741842. - Review
    Faithful transmission of genetic material in eukaryotic cells requires not only accurate DNA replication and chromosome distribution but also the ability to sense and rep …
  • MicroRNAs, the DNA Damage Response and Cancer
    MD Wouters et al. Mutat Res 717 (1-2), 54-66. PMID 21477600. - Review
    Many carcinogenic agents such as ultra-violet light from the sun and various natural and man-made chemicals act by damaging the DNA. To deal with these potentially detrim …
  • MicroRNAs and DNA Damage Response: Implications for Cancer Therapy
    Y Wang et al. Cell Cycle 12 (1), 32-42. PMID 23255103. - Review
    The DNA damage response (DDR) pathways play critical roles in protecting the genome from DNA damage. Abrogation of DDR often results in elevated genomic instability and c …
  • [The Post-Transcriptional Regulation of the DNA Damage Response]
    D Lin et al. Yi Chuan 36 (4), 309-15. PMID 24846975. - Review
    In response to DNA damage, a complex signaling network called DNA damage response (DDR) would be activated in cells, to arrest the cell cycle and initiate DNA repair. Pre …
See all similar articles

Cited by 23 PubMed Central articles

See all "Cited by" articles


    1. Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature. 2009;461(7267):1071–1078. - PMC - PubMed
    1. Ward I, Chen J. Early events in the DNA damage response. Current Topics in Developmental Biology. 2004;63:1–35. - PubMed
    1. Vigneron A, Cherier J, Barré B, Gamelin E, Coqueret O. The cell cycle inhibitor p21-waf1 binds to the myc and cdc25a promoters upon DNA damage and induces transcriptional repression. Journal of Biological Chemistry. 2006;281(46):34742–34750. - PubMed
    1. Ciccia A, Elledge SJ. The DNA damage response: making it safe to play with knives. Molecular Cell. 2010;40(2):179–204. - PMC - PubMed
    1. Matsuoka S, Ballif BA, Smogorzewska A, et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007;316(5828):1160–1166. - PubMed

LinkOut - more resources