Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases

Chem Commun (Camb). 2014 Apr 21;50(31):4096-8. doi: 10.1039/c3cc49198f.


Benzoselenadiazole-containing inhibitors of protein kinases were constructed and their capability to emit phosphorescence in the kinase-bound state was established. Labelling of the inhibitors with a red fluorescent dye led to sensitive responsive photoluminescent probes for protein kinase CK2 that emitted red light with a long (microsecond-scale) decay time upon excitation of the probes with a pulse of near-UV light.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azoles / chemistry*
  • Azoles / radiation effects
  • Casein Kinase II / chemistry*
  • Coloring Agents / chemistry*
  • Coloring Agents / radiation effects
  • Cyclic AMP-Dependent Protein Kinases / chemistry
  • Light
  • Organoselenium Compounds / chemistry*
  • Organoselenium Compounds / radiation effects
  • Peptides / chemistry*
  • Peptides / radiation effects
  • Proto-Oncogene Proteins c-pim-1 / chemistry


  • Azoles
  • Coloring Agents
  • Organoselenium Compounds
  • Peptides
  • Casein Kinase II
  • Proto-Oncogene Proteins c-pim-1
  • Cyclic AMP-Dependent Protein Kinases