Construction of a crown ether-like supramolecular library by conjugation of genetically-encoded peptide linkers displayed on bacteriophage T7

Keisuke Fukunaga; Takaaki Hatanaka; Yuji Ito; Michiko Minami; Masumi Taki

doi:10.1039/c4cc00811a

Construction of a crown ether-like supramolecular library by conjugation of genetically-encoded peptide linkers displayed on bacteriophage T7

Chem Commun (Camb). 2014 Apr 18;50(30):3921-3. doi: 10.1039/c4cc00811a. Epub 2014 Mar 11.

Authors

Keisuke Fukunaga¹, Takaaki Hatanaka, Yuji Ito, Michiko Minami, Masumi Taki

Affiliation

¹ Department of Engineering Science, Bioscience and Technology Program, The Graduate School of Informatics and Engineering, The University of Electro-Communications (UEC), 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan. taki@pc.uec.ac.jp.

PMID: 24619095
DOI: 10.1039/c4cc00811a

Abstract

By using the 10BASEd-T, we have synthesized a crown ether-like macrocyclic library possessing randomized peptide linkers on bacteriophage T7. Among 1.5 × 10(9) diversities of the supramolecule candidates, we have obtained a specific binder for the N-terminal domain of Hsp90.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacteriophage T7 / genetics*
Crown Ethers / chemical synthesis*
Crown Ethers / chemistry*
Macromolecular Substances / chemical synthesis*
Macromolecular Substances / chemistry*
Molecular Structure
Peptides / chemistry*
Peptides / genetics*

Substances

Crown Ethers
Macromolecular Substances
Peptides