Limb regeneration in salamanders and digital tip regeneration in experimental mice: implications for the hand surgeon

J Hand Surg Eur Vol. 2014 Nov;39(9):989-93. doi: 10.1177/1753193414526109. Epub 2014 Mar 11.

Abstract

Several lessons and observations from limb regeneration in animals could open new insights to direct related research in the field of hand surgery. This article briefly reviews the biology of limb regeneration in salamanders and experimental mice, with special emphasis on implications for hand surgery.

Level of evidence: 5.

Keywords: hand; mice; nAG; regeneration; salamander.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Animals, Newborn / physiology*
  • Bone Morphogenetic Protein 4 / physiology
  • Fetal Development / physiology
  • Finger Injuries / physiopathology
  • Finger Injuries / surgery
  • Forelimb / physiology*
  • Hindlimb / physiology*
  • Homeodomain Proteins / physiology
  • Humans
  • Limb Buds / drug effects
  • Limb Buds / physiology
  • Mice / physiology*
  • Regeneration / drug effects
  • Regeneration / physiology*
  • Species Specificity
  • Translational Medical Research
  • Tretinoin / pharmacology
  • Urodela / physiology*

Substances

  • Bmp4 protein, mouse
  • Bone Morphogenetic Protein 4
  • Homeodomain Proteins
  • Tretinoin