Whole cell currents and mechanical responses of isolated outer hair cells

Hear Res. 1988 Sep 15;35(2-3):143-50. doi: 10.1016/0378-5955(88)90113-x.


Outer hair cells (OHCs) exhibit electrically induced cell movements which are considered to enhance the frequency selectivity and sensitivity of basilar membrane vibration. Using simultaneous whole cell voltage clamp and video analysis, we demonstrate that the mechanical response of OHCs is not altered by agents which alter membrane currents under voltage clamp. Thus the underlying mechanism of OHC movements appears to be dependent upon membrane potential, rather than transmembrane currents.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Movement / drug effects
  • Guinea Pigs
  • Hair Cells, Auditory / physiology*
  • Ion Channels / drug effects
  • Membrane Potentials / drug effects


  • Ion Channels