Induction of pluripotency by defined factors

Proc Jpn Acad Ser B Phys Biol Sci. 2014;90(3):83-96. doi: 10.2183/pjab.90.83.


The "reversion of cell fate from differentiated states back into totipotent or pluripotent states" has been an interest of many scientists for a long time. With the help of knowledge accumulated by those scientists, we succeeded in converting somatic cells to a pluripotent cell lineage by the forced expression of defined factors. These established induced pluripotent stem (iPS) cells have similar features to embryonic stem (ES) cells, including pluripotency and immortality. The iPS cell technology provides unprecedented opportunities for regenerative medicine and drug discovery.

Publication types

  • Review

MeSH terms

  • Animals
  • Cellular Reprogramming / drug effects
  • Drug Discovery
  • Humans
  • Induced Pluripotent Stem Cells / cytology*
  • Induced Pluripotent Stem Cells / drug effects
  • Induced Pluripotent Stem Cells / metabolism*
  • Regenerative Medicine