The tachykinin NH2-senktide, a selective neurokinin B receptor agonist, is a very potent inhibitor of salt appetite in the rat

Neurosci Lett. 1988 Oct 17;92(3):341-6. doi: 10.1016/0304-3940(88)90614-3.

Abstract

The tachykinin peptide [Asp5.6, MePhe8]substance P(5-11) (NH2-senktide), a senktide analogue lacking the N-terminal succinyl group, is a selective and metabolically stable NK-3 receptor agonist. In the present study it potently inhibited salt appetite induced by sodium depletion in rats. Argo-neurokinin B, too, inhibited salt appetite, but was less potent than NH2-senktide. Neither peptide inhibited drinking behaviour induced by subcutaneous hypertonic NaCl. NH2-senktide slightly inhibited angiotensin-induced drinking, while Argo-neurokinin B was ineffective. On the other hand, eledoisin was a potent inhibitor in the 3 behavioural tests. Present results indicate that activation of NK-3 receptors is involved in the antinatriorexic action of tachykinins, and that different receptor subtypes might be involved in the different effects of tachykinins on the rat ingestive behaviour.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Appetite / drug effects*
  • Dose-Response Relationship, Drug
  • Injections, Intraventricular
  • Male
  • Neurokinin B / pharmacology
  • Peptide Fragments / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Receptors, Neurokinin-3
  • Receptors, Neurotransmitter / drug effects
  • Receptors, Neurotransmitter / physiology*
  • Sodium Chloride*
  • Substance P / analogs & derivatives*
  • Substance P / pharmacology
  • Tachykinins / pharmacology*

Substances

  • Peptide Fragments
  • Receptors, Neurokinin-3
  • Receptors, Neurotransmitter
  • Tachykinins
  • substance P (5-11), Asp(5,6)-MePhe(8)-
  • Substance P
  • Sodium Chloride
  • Neurokinin B