Restoring immune balance in type 1 diabetes
- PMID: 24622404
- DOI: 10.1016/S2213-8587(13)70123-2
Restoring immune balance in type 1 diabetes
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Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial.Lancet Diabetes Endocrinol. 2013 Dec;1(4):284-94. doi: 10.1016/S2213-8587(13)70111-6. Epub 2013 Sep 23. Lancet Diabetes Endocrinol. 2013. PMID: 24622414 Free PMC article. Clinical Trial.
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Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial.Lancet Diabetes Endocrinol. 2013 Dec;1(4):284-94. doi: 10.1016/S2213-8587(13)70111-6. Epub 2013 Sep 23. Lancet Diabetes Endocrinol. 2013. PMID: 24622414 Free PMC article. Clinical Trial.
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Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients.J Clin Invest. 2015 Aug 3;125(8):3285-96. doi: 10.1172/JCI81722. Epub 2015 Jul 20. J Clin Invest. 2015. PMID: 26193635 Free PMC article. Clinical Trial.
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Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis.J Transl Med. 2007 Jun 7;5:27. doi: 10.1186/1479-5876-5-27. J Transl Med. 2007. PMID: 17555598 Free PMC article. Clinical Trial.
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Biologic therapy for psoriasis: the T-cell-targeted therapies efalizumab and alefacept.Cutis. 2003 Jan;71(1):41-5. Cutis. 2003. PMID: 12553629 Review.
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Conversion of Gastrointestinal Somatostatin-Expressing D Cells Into Insulin-Producing Beta-Like Cells Upon Pax4 Misexpression.Front Endocrinol (Lausanne). 2022 Apr 29;13:861922. doi: 10.3389/fendo.2022.861922. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35573999 Free PMC article.
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Decreased expression of programmed death-1 on CD8+ effector memory T lymphocytes correlates with the pathogenesis of type 1 diabetes.Acta Diabetol. 2021 Sep;58(9):1239-1249. doi: 10.1007/s00592-021-01711-z. Epub 2021 Apr 23. Acta Diabetol. 2021. PMID: 33890177
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