Perfluoroalkyl acids in blood serum samples from children in Taiwan

Environ Sci Pollut Res Int. 2014 Jun;21(12):7650-5. doi: 10.1007/s11356-014-2594-4. Epub 2014 Mar 13.


Severe perfluoroalkyl acid (PFAA) contamination resulting from the fast-growing semiconductor, electrochemical, and optoelectronic industries has been determined in the river water in the vicinity of the Taipei area, Taiwan, during recent years. However, little is known about body burdens of the PFAA contaminations in local residents, especially children living in the Taipei area recently. In this study, ten target PFAA analytes consisted of three perfluorosulfonates (PFSAs) and seven perfluorocarboxylates (PFCAs) in the blood serum samples, collected from 225 healthy children with an average age of 13.6 years in the Taipei area from 2009 to 2010, were analyzed via high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). As the dominant PFAA contaminant in the blood serum samples from Taiwanese children, perfluorooctane sulfonate (PFOS) contributed 86% of all the target PFAA analytes, while the other nine analytes contributed less than 5% individually. PFOS showed the highest median up to 29 ng/mL, ranging from 0.03 to 148 ng/mL, which was higher than that observed in the serum samples collected from Taiwanese children between 2006 and 2008. Statistically, serum concentrations of perfluorobutane sulfonate (PFBS), perfluorohexane sulfonate (PFHxS), and perfluorooctanoic acid (PFOA) had significantly positive correlations with ages of children (p < 0.05). Furthermore, serum PFBS, PFHxS, and PFOA concentrations in the male children were considerably higher than those in the female children (p = 0.049, p = 0.000, p = 0.000).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Alkanesulfonic Acids / blood
  • Caprylates / blood
  • Child
  • Chromatography, High Pressure Liquid
  • Female
  • Fluorocarbons / blood*
  • Humans
  • Male
  • Rivers
  • Taiwan
  • Tandem Mass Spectrometry
  • Water Pollutants, Chemical / blood*


  • Alkanesulfonic Acids
  • Caprylates
  • Fluorocarbons
  • Water Pollutants, Chemical
  • perfluorooctanoic acid
  • perfluorooctane sulfonic acid
  • perflexane
  • perfluorobutane