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Pancreatic Cancer Cachexia: A Review of Mechanisms and Therapeutics


Pancreatic Cancer Cachexia: A Review of Mechanisms and Therapeutics

Carlyn R Tan et al. Front Physiol.


Over the last decade, we have gained new insight into the pathophysiology of cachexia associated with pancreatic cancer. Unfortunately, its treatment is complex and remains a challenge. Pancreatic cancer cachexia is a multifactorial syndrome characterized by uncompensated adipose tissue and skeletal muscle loss in the setting of anorexia that leads to progressive functional impairment. This paper will review the current concepts of pancreatic cancer cachexia, its assessment and pathophysiology as well as current and future treatments. The successful management of pancreatic cancer cachexia will likely require a multimodal approach that includes nutritional support and combination pharmaceutical interventions.

Keywords: anorexia; cachexia; catabolism; multimodal therapy; pancreatic cancer.


Figure 1
Figure 1
Proposed mechanisms of pancreatic cancer cachexia.

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    1. Ando K., Takahashi F., Motojima S., Nakashima K., Kaneko N., Hoshi K., et al. (2013). Possible role for tocilizumab, an anti-interleukin-6 receptor antibody, in treating cancer cachexia. J. Clin. Oncol. 31, e69–e72 10.1200/JCO.2012.44.2020 - DOI - PubMed
    1. Arruda A. P., Milanski M., Romanatto T., Solon C., Coope A., Alberici L. C., et al. (2010). Hypothalamic actions of tumor necrosis factor alpha provide the thermogenic core for the wastage syndrome in cachexia. Endocrinology 151, 683–694 10.1210/en.2009-0865 - DOI - PubMed
    1. Bachmann J., Heiligensetzer M., Krakowski-Roosen H., Büchler M. W., Friess H., Martignoni M. E. (2008). Cachexia worsens prognosis in patients with resectable pancreatic cancer. J. Gastrointest. Surg. 12, 1193–1201 10.1007/s11605-008-0505-z - DOI - PubMed
    1. Bachmann J., Ketterer K., Marsch C., Fechtner K., Krakowski-Roosen H., Buchler M. W., et al. (2009). Pancreatic cancer related cachexia: influence on metabolism and correlation to weight loss and pulmonary function. BMC Cancer 9:255 10.1186/1471-2407-9-255 - DOI - PMC - PubMed
    1. Barber M. D., Ross J. A., Voss A. C., Tisdale M. J., Fearon K. C. (1999). The effect of an oral nutritional supplement enriched with fish oil on weight-loss in patients with pancreatic cancer. Br. J. Cancer 81, 80–86 10.1038/sj.bjc.6690654 - DOI - PMC - PubMed

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