Invasive pulmonary aspergillosis post extracorporeal membrane oxygenation support and literature review

Benjamin J Parcell; Pavan Kumar B C Raju; Elizabeth M Johnson; Thomas C Fardon; William J Olver

doi:10.1016/j.mmcr.2014.01.003

Invasive pulmonary aspergillosis post extracorporeal membrane oxygenation support and literature review

Med Mycol Case Rep. 2014 Feb 10:4:12-5. doi: 10.1016/j.mmcr.2014.01.003. eCollection 2014 Apr.

Authors

Benjamin J Parcell¹, Pavan Kumar B C Raju², Elizabeth M Johnson³, Thomas C Fardon⁴, William J Olver¹

Affiliations

¹ Department of Medical Microbiology, Ninewells Hospital and Medical School, Dundee, NHS Tayside, DD1 9SY Scotland, UK.
² Anaesthetic Department, Ninewells Hospital and Medical School, Dundee, NHS Tayside, DD1 9SY Scotland, UK.
³ Public Health England Mycology Reference Laboratory and National Collection of Pathogenic Fungi, PHE South West Laboratory, Myrtle Road, Kingsdown, Bristol BS2 8EL, England, UK.
⁴ Department of Respiratory Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK.

Abstract

The use of extracorporeal membrane oxygenation (ECMO) for reversible pulmonary failure in critically ill patients has increased over the last few decades. Nosocomial infections are a major complication of ECMO and fungi have been found to be a common cause. Herein, we describe a case of invasive pulmonary aspergillosis following ECMO, which was successfully treated with combination antifungal therapy and interferon-gamma.

Keywords: Anidulafungin; Aspergillus fumigatus; Extracorporeal membrane oxygenation support.