Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate

Nature. 1988 Dec 22-29;336(6201):738-44. doi: 10.1038/336738a0.


cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation. One site of cdc2 tyrosine phosphorylation in vivo is selectively phosphorylated by pp60c-src in vitro.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • CDC2 Protein Kinase
  • Cell Cycle*
  • HeLa Cells
  • Mitosis
  • Phosphoproteins / metabolism*
  • Phosphotyrosine
  • Protein-Tyrosine Kinases / metabolism*
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins pp60(c-src)
  • Tyrosine / analogs & derivatives
  • Tyrosine / metabolism


  • Phosphoproteins
  • Proto-Oncogene Proteins
  • Phosphotyrosine
  • Tyrosine
  • Protein-Tyrosine Kinases
  • Proto-Oncogene Proteins pp60(c-src)
  • CDC2 Protein Kinase