Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Mar;21(3):236-43.
doi: 10.1111/acem.12328.

Rising Opioid Prescribing in Adult U.S. Emergency Department Visits: 2001-2010

Free article

Rising Opioid Prescribing in Adult U.S. Emergency Department Visits: 2001-2010

Maryann Mazer-Amirshahi et al. Acad Emerg Med. .
Free article


Objectives: The objective was to describe trends in opioid and nonopioid analgesia prescribing for adults in U.S. emergency departments (EDs) over the past decade.

Methods: Data from the National Hospital Ambulatory Medical Care Survey (NHAMCS) 2001 through 2010 were analyzed. ED visits for adult patients (≥18 years of age) during which an analgesic was prescribed were included. Trends in the use of six commonly prescribed opioids, stratified by Drug Enforcement Agency (DEA) schedule, as well as nonopioid analgesics were explored, along with the frequency of pain-related ED visits. For 2005 through 2010, data were further divided by whether the opioid was administered in the ED versus prescribed at discharge.

Results: Between 2001 and 2010, the percentage of overall ED visits (pain-related and non-pain-related) where any opioid analgesic was prescribed increased from 20.8% to 31.0%, an absolute increase of 10.2% (95% confidence interval [CI] = 7.0% to 13.4%) and a relative increase of 49.0%. Use of DEA schedule II analgesics increased from 7.6% in 2001 to 14.5% in 2010, an absolute increase of 6.9% (95% CI = 5.2% to 8.5%) and a relative increase of 90.8%. Use of schedule III through V agents increased from 12.6% in 2001 to 15.6% in 2010, an absolute increase of 3.0% (95% CI = 2.0% to 5.7%) and a relative increase of 23.8%. Prescribing of hydrocodone, hydromorphone, morphine, and oxycodone all increased significantly, while codeine and meperidine use declined. Prescribing of nonopioid analgesics was unchanged, 26.2% in 2001 and 27.3% in 2010 (95% CI = -1.0% to 3.4%). Hydromorphone and oxycodone had the greatest increase in ED administration between 2005 and 2010, while oxycodone and hydrocodone had the greatest increases in discharge prescriptions. There was no difference in discharge prescriptions for nonopioid analgesics. The percentage of visits for painful conditions during the period increased from 47.1% in 2001 to 51.1% in 2010, an absolute increase of 4.0% (95% CI = 2.3% to 5.8%).

Conclusions: There has been a dramatic increase in prescribing of opioid analgesics in U.S. EDs in the past decade, coupled with a modest increase in pain-related complaints. Prescribing of nonopioid analgesics did not significantly change.

Comment in

  • In reply.
    Mazer-Amirshahi M, Mullins PM, Rasooly I, van den Anker J, Pines JM. Mazer-Amirshahi M, et al. Acad Emerg Med. 2014 Aug;21(8):947. doi: 10.1111/acem.12433. Epub 2014 Aug 25. Acad Emerg Med. 2014. PMID: 25154412 No abstract available.
  • Are discharge prescriptions of opioids from the emergency department truly rising?
    Kea B, Fu R, Deyo RA, Sun BC. Kea B, et al. Acad Emerg Med. 2014 Aug;21(8):946. doi: 10.1111/acem.12425. Epub 2014 Aug 25. Acad Emerg Med. 2014. PMID: 25156157 Free PMC article. No abstract available.

Similar articles

See all similar articles

Cited by 49 articles

See all "Cited by" articles