More than just a filler - the role of hyaluronan for skin homeostasis

Exp Dermatol. 2014 May;23(5):295-303. doi: 10.1111/exd.12370.


In recent years, hyaluronan (HA) has become an increasingly attractive substance as a non-immunogenic filler and scaffolding material in cosmetic dermatology. Despite its wide use for skin augmentation and rejuvenation, relatively little is known about the molecular structures and interacting proteins of HA in normal and diseased skin. However, a comprehensive understanding of cutaneous HA homeostasis is required for future the development of HA-based applications for skin regeneration. This review provides an update on HA-based structures, expression, metabolism and its regulation, function and pharmacological targeting of HA in skin.

Keywords: fillers; hyaluronan; metabolism; skin; skin regeneration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biocompatible Materials
  • Cosmetics / chemistry
  • Dermatology
  • Face
  • Homeostasis
  • Humans
  • Hyaluronan Receptors / metabolism
  • Hyaluronic Acid / chemistry
  • Hyaluronic Acid / physiology*
  • Ligands
  • Regeneration
  • Signal Transduction
  • Skin
  • Skin Aging
  • Skin Physiological Phenomena*


  • Biocompatible Materials
  • Cosmetics
  • Hyaluronan Receptors
  • Ligands
  • Hyaluronic Acid