LINE(1)s of evidence in HBV-driven liver cancer

Mathias Heikenwalder; Ulrike Protzer

doi:10.1016/j.chom.2014.02.015

LINE(1)s of evidence in HBV-driven liver cancer

Cell Host Microbe. 2014 Mar 12;15(3):249-50. doi: 10.1016/j.chom.2014.02.015.

Authors

Mathias Heikenwalder¹, Ulrike Protzer²

Affiliations

¹ Institute of Virology, Technische Universität München/Helmholtz Zentrum München, 81675 Munich, Germany. Electronic address: heikenwaelder@helmholtz-muenchen.de.
² Institute of Virology, Technische Universität München/Helmholtz Zentrum München, 81675 Munich, Germany. Electronic address: protzer@tum.de.

PMID: 24629329
DOI: 10.1016/j.chom.2014.02.015

Abstract

Hepatitis B virus (HBV) integration in hepatocellular carcinoma (HCC) is a poorly understood event. In a recent Cancer Cell paper, Lau et al. (2014) describe a HBV-human fusion transcript (HBx-LINE1) that functions as a lncRNA, influences the epithelial-mesenchymal transition, and correlates with reduced patient survival and tumor formation in mice.

Publication types

Comment

MeSH terms

Animals
Carcinoma, Hepatocellular / genetics*
DNA-Binding Proteins / genetics*
Humans
Liver Neoplasms / genetics*
Trans-Activators / genetics*
Viral Fusion Proteins / genetics*

Substances

DNA-Binding Proteins
Trans-Activators
Viral Fusion Proteins