Brain derived neurotrophic factor in the retina of the teleost N. furzeri

Ann Anat. 2014 Jul;196(4):192-6. doi: 10.1016/j.aanat.2014.01.002. Epub 2014 Feb 6.


BDNF plays an important role in the development and maintenance of visual circuitries in the retina and brain visual centers. In adulthood, BDNF signaling is involved in neural protection and regeneration of retina. In this survey, we investigated the expression of BDNF in the retina of adult Nothobranchius furzeri, a teleost fish employed for age research. After describing the retina of N. furzeri and confirming that the structure is organized in layers as in all vertebrates, we have studied the localization of BDNF mRNA and protein throughout the retinal layers. BDNF mRNA is detectable in all layers, whereas the protein is lacking in the photoreceptors. The occurrence of BDNF provides new insights on its role in the retina, particularly in view of age-related disease of retina.

Keywords: BDNF; Retina; Teleost.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / physiology
  • Animals
  • Biomarkers
  • Brain-Derived Neurotrophic Factor / chemistry
  • Brain-Derived Neurotrophic Factor / metabolism*
  • Cyprinodontiformes / physiology*
  • Mitochondria / physiology
  • Photoreceptor Cells, Vertebrate / physiology
  • Photoreceptor Cells, Vertebrate / ultrastructure
  • Retina / growth & development
  • Retina / metabolism*
  • Telomere Shortening / physiology


  • Biomarkers
  • Brain-Derived Neurotrophic Factor