[Association between SNPs in DNMT1 and noise-induced hearing loss in Chinese Han population]

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2014 Feb;32(2):104-7.
[Article in Chinese]

Abstract

Objective: To investigate the association between single nucleotide polymorphisms (SNPs) in DNA methyltransferase 1 (DNMT1) (rs12984523, rs16999593, and rs2228612) and noise-induced hearing loss (NIHL) in Chinese Han population.

Methods: This case-control study consisted of 188 cases (case group) and 300 controls (control group) in the same working position, who were matched for age and gender. The cases had a binaural average high-frequency hearing threshold not less than 40 dB, and the controls had a binaural average high-frequency hearing threshold less than 40 dB. The genotypes at the three SNPs were determined by TaqMan probe.

Results: TT genotype at DNMT1 rs2228612 is a risk factor for NIHL (adjusted OR = 1.69, 95% CI: 1.14-2.52).

Conclusion: The study of Chinese Han population suggested that DNMT1 rs2228612 is associated with susceptibility to NIHL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asian People / genetics
  • Auditory Threshold
  • Case-Control Studies
  • DNA (Cytosine-5-)-Methyltransferase 1
  • DNA (Cytosine-5-)-Methyltransferases / genetics*
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Haplotypes
  • Hearing Loss, Noise-Induced / genetics*
  • Humans
  • Male
  • Middle Aged
  • Noise, Occupational
  • Polymorphism, Single Nucleotide*
  • Risk Factors

Substances

  • DNA (Cytosine-5-)-Methyltransferase 1
  • DNA (Cytosine-5-)-Methyltransferases
  • DNMT1 protein, human