The impact of multidrug resistance on outcomes in ventilator-associated pneumonia

Am J Infect Control. 2014 May;42(5):542-5. doi: 10.1016/j.ajic.2013.12.009. Epub 2014 Mar 14.

Abstract

Multidrug-resistant (MDR) organisms in ventilator-associated pneumonia were found in 49 of 107 patients and were associated with home antibiotics, pre-ventilator-associated pneumonia hospital stay, and health care exposure. Overall, MDR organisms were associated with increased mortality (P = .006). On multivariate analysis, MDR status was modulated by organism class. In nonfermenting gram-negative rods, no association between MDR and mortality was found, but, in all other organisms, MDR was associated with increased mortality risk (hazard ratio, 6.15; 95% confidence interval: 1.80-21.05, P = .004).

Keywords: Hospital-acquired infections; Intensive care units; Multidrug-resistant organisms; Pseudomonas aeruginosa.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / therapeutic use*
  • Bacteria / drug effects*
  • Bacteria / isolation & purification
  • Drug Resistance, Multiple, Bacterial*
  • Female
  • Humans
  • Intensive Care Units
  • Male
  • Middle Aged
  • Pneumonia, Ventilator-Associated / drug therapy*
  • Pneumonia, Ventilator-Associated / microbiology
  • Pneumonia, Ventilator-Associated / mortality
  • Retrospective Studies
  • Risk Factors
  • Survival Analysis
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents