Sugarcoating ER Stress

Cell. 2014 Mar 13;156(6):1125-1127. doi: 10.1016/j.cell.2014.02.035.

Abstract

The hexosamine biosynthetic pathway (HBP) generates metabolites for protein N- and O-glycosylation. Wang et al. and Denzel et al. report a hitherto unknown link between the HBP and stress in the endoplasmic reticulum. These studies establish the HBP as a critical component of the cellular machinery of protein homeostasis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Biosynthetic Pathways*
  • Caenorhabditis elegans / metabolism*
  • Caenorhabditis elegans Proteins / metabolism*
  • DNA-Binding Proteins / metabolism*
  • Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / metabolism*
  • Hexosamines / metabolism*
  • Humans
  • Longevity*
  • Male
  • Proteins / metabolism*
  • Regulatory Factor X Transcription Factors
  • Transcription Factors / metabolism*
  • Unfolded Protein Response*

Substances

  • Caenorhabditis elegans Proteins
  • DNA-Binding Proteins
  • Hexosamines
  • Proteins
  • Regulatory Factor X Transcription Factors
  • Transcription Factors
  • Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)