Abstract
The hexosamine biosynthetic pathway (HBP) generates metabolites for protein N- and O-glycosylation. Wang et al. and Denzel et al. report a hitherto unknown link between the HBP and stress in the endoplasmic reticulum. These studies establish the HBP as a critical component of the cellular machinery of protein homeostasis.
Copyright © 2014 Elsevier Inc. All rights reserved.
MeSH terms
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Animals
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Biosynthetic Pathways*
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Caenorhabditis elegans / metabolism*
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Caenorhabditis elegans Proteins / metabolism*
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DNA-Binding Proteins / metabolism*
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Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / metabolism*
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Hexosamines / metabolism*
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Humans
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Longevity*
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Male
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Proteins / metabolism*
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Regulatory Factor X Transcription Factors
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Transcription Factors / metabolism*
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Unfolded Protein Response*
Substances
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Caenorhabditis elegans Proteins
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DNA-Binding Proteins
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Hexosamines
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Proteins
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Regulatory Factor X Transcription Factors
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Transcription Factors
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Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)