SnapShot: talin and the modular nature of the integrin adhesome

Cell. 2014 Mar 13;156(6):1340-1340.e1. doi: 10.1016/j.cell.2014.02.048.


Integrin αβ transmembrane heterodimers play central roles in metazoan development and physiology by mediating adhesion and by transmitting forces and biochemical signals across the plasma membrane. In this SnapShot, we present a simplified "modular" view of the integrin adhesome, centered on the talin-integrin interaction, and provide examples of how this view can help to unravel the adhesome's remarkable functional diversity and plasticity.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Adhesion
  • Integrins / chemistry
  • Integrins / metabolism*
  • Molecular Sequence Data
  • Talin / chemistry
  • Talin / metabolism*


  • Integrins
  • Talin