Nonhomologous end joining: a good solution for bad ends

DNA Repair (Amst). 2014 May;17:39-51. doi: 10.1016/j.dnarep.2014.02.008. Epub 2014 Mar 14.


Double strand breaks pose unique problems for DNA repair, especially when broken ends possess complex structures that interfere with standard DNA transactions. Nonhomologous end joining can use multiple strategies to solve these problems. It further uses sophisticated means to ensure the strategy chosen provides the ideal balance of flexibility and accuracy.

Keywords: DNA damage; Double strand break repair; Nonhomologous end joining.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Binding Sites
  • DNA Breaks, Double-Stranded*
  • DNA End-Joining Repair*
  • DNA Repair Enzymes / chemistry*
  • DNA Repair Enzymes / metabolism*
  • Humans
  • Models, Molecular


  • DNA Repair Enzymes