Epiregulin: roles in normal physiology and cancer

Semin Cell Dev Biol. 2014 Apr;28:49-56. doi: 10.1016/j.semcdb.2014.03.005. Epub 2014 Mar 12.

Abstract

Epiregulin is a 46-amino acid protein that belongs to the epidermal growth factor (EGF) family of peptide hormones. Epiregulin binds to the EGF receptor (EGFR/ErbB1) and ErbB4 (HER4) and can stimulate signaling of ErbB2 (HER2/Neu) and ErbB3 (HER3) through ligand-induced heterodimerization with a cognate receptor. Epiregulin possesses a range of functions in both normal physiologic states as well as in pathologic conditions. Epiregulin contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation. Deregulated epiregulin activity appears to contribute to the progression of a number of different malignancies, including cancers of the bladder, stomach, colon, breast, lung, head and neck, and liver. Therefore, epiregulin and the elements of the EGF/ErbB signaling network that lie downstream of epiregulin appear to be good targets for therapeutic intervention.

Keywords: EGF/ErbB receptors; Epiregulin; Epithelial cell proliferation; Inflammation; Oocyte maturation; Tumor Progression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Proliferation / physiology
  • Epidermal Growth Factor / metabolism*
  • Epiregulin / metabolism*
  • ErbB Receptors / metabolism*
  • Humans
  • Neoplasms / metabolism*
  • Signal Transduction / physiology

Substances

  • Epiregulin
  • Epidermal Growth Factor
  • ErbB Receptors