Long non-coding RNA Loc554202 regulates proliferation and migration in breast cancer cells

Biochem Biophys Res Commun. 2014 Apr 4;446(2):448-53. doi: 10.1016/j.bbrc.2014.02.144. Epub 2014 Mar 12.

Abstract

Data derived from massive cloning and traditional sequencing methods have revealed that long non-coding RNAs (lncRNA) play important roles in the development and progression of cancer. Although many studies suggest that the lncRNAs have different cellular functions, many of them are not yet to be identified and characterized for the mechanism of their functions. To address this question, we assay the expression level of lncRNAs-Loc554202 in breast cancer tissues and find that Loc554202 is significantly increased compared with normal control, and associated with advanced pathologic stage and tumor size. Moreover, knockdown of Loc554202 decreased breast cancer cell proliferation, induced apoptosis and inhibits migration/invasion in vitro and impeded tumorigenesis in vivo. These data suggest an important role of Loc554202 in breast tumorigenesis.

Keywords: Breast cancer; Loc554202; lncRNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology*
  • Cell Line, Tumor
  • Cell Movement / genetics
  • Cell Proliferation
  • Female
  • Gene Expression Regulation, Neoplastic / genetics*
  • Humans
  • Molecular Sequence Data
  • RNA, Long Noncoding / genetics*

Substances

  • RNA, Long Noncoding