Molecular recognition of curcumin (Indian Ayurvedic medicine) by the supramolecular probe, p-t-butyl calix(8)arene

Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jun 5;127:172-6. doi: 10.1016/j.saa.2014.02.027. Epub 2014 Feb 22.

Abstract

The thermodynamic property of the host-guest complexes formed between the curcumin, component of Indian Ayurvedic medicine turmeric, a drug molecule, with the supra molecule, p-t-butyl calix(8)arene was studied. p-t-Butyl calix(8)arene has been used as a host molecule and curcumin as a guest molecule. Optical absorption spectral studies were carried out to investigate the molecular recognition properties of p-t-butyl calix(8)arene with curcumin. The stochiometry of the host-guest complexes formed and the binding constant were determined. An interesting 1:1 and 4:1 stochiometric host-guest complexes were formed. Job's continuous method of variation and Benesi-Hildebrand expression were used for the determination of binding constant and the stochiometry of the host-guest complex formed.

Keywords: Component of Indian Ayurvedic medicine; Curcumin; Drug molecule; Molecular recognition; P-t-butyl calix(8)arene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / chemistry*
  • Calixarenes / chemistry*
  • Curcumin / chemistry*
  • Medicine, Ayurvedic*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Calixarenes
  • Curcumin