Progress, prospects, and problems in Epstein-Barr virus vaccine development

Curr Opin Virol. 2014 Jun:6:1-5. doi: 10.1016/j.coviro.2014.02.005. Epub 2014 Mar 15.


Epstein-Barr virus (EBV) is responsible for a farrago of acute and chronic human diseases including cancer. A prophylactic vaccine could reduce this disease burden. Several EBV vaccines have been given to humans but none has been sufficiently studied to establish safety and efficacy. EBV vaccine development has been hampered by the lack of an animal model other than subhuman primates, proprietary issues, selection of an appropriate adjuvant, and failure to reach consensus on what an EBV vaccine could or should actually achieve. A recent conference at the U.S. National Institutes of Health emphasizing the global importance of EBV vaccine and advocating a phase 3 trial to prevent infectious mononucleosis should encourage research that could eventually lead to its licensure.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Clinical Trials as Topic
  • Epstein-Barr Virus Infections / immunology*
  • Epstein-Barr Virus Infections / prevention & control*
  • Herpesvirus 4, Human / immunology*
  • Humans
  • Infectious Mononucleosis / immunology
  • Infectious Mononucleosis / prevention & control
  • Viral Vaccines / administration & dosage
  • Viral Vaccines / immunology*


  • Viral Vaccines