Innate immunity in disease

Clin Gastroenterol Hepatol. 2014 May;12(5):749-55. doi: 10.1016/j.cgh.2014.03.007. Epub 2014 Mar 12.


Cells can innately recognize generic products of viruses, bacteria, fungi, or injured tissue by engagement of pattern recognition receptors. Innate immune cells rapidly respond to this engagement to control commensals, thwart pathogens, and/or prompt repair. Insufficient or excessive activation of the innate immune response results in disease. This review focuses on pattern recognition receptors and cells of the innate immune system that are important for intestinal function. Our improving knowledge pertaining to this important aspect of our immune response is opening potential important new therapeutic opportunities for the treatment of disease.

Keywords: Colitis; Gastroenterology; Innate Immunity; Mucosa.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cytokines / metabolism
  • Gastrointestinal Diseases / immunology*
  • Gastrointestinal Diseases / pathology*
  • Humans
  • Immunity, Innate*
  • Leukocytes / immunology
  • Receptors, Pattern Recognition / metabolism


  • Cytokines
  • Receptors, Pattern Recognition