Unbalanced excitability underlies offline reactivation of behaviorally activated neurons

Nat Neurosci. 2014 Apr;17(4):503-5. doi: 10.1038/nn.3674. Epub 2014 Mar 16.

Abstract

Hippocampal sharp waves (SWs)/ripples represent the reactivation of neurons involved in recently acquired memory and are crucial for memory consolidation. By labeling active cells with fluorescent protein under the control of an immediate-early gene promoter, we found that neurons that had been activated while mice explored a novel environment were preferentially reactivated during spontaneous SWs in hippocampal slices in vitro. During SWs, the reactivated neurons received strong excitatory synaptic inputs as opposed to a globally tuned network balance between excitation and inhibition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / physiology*
  • Exploratory Behavior / physiology*
  • Female
  • Genes, Immediate-Early / genetics
  • Genes, Immediate-Early / physiology
  • Hippocampus / cytology
  • Hippocampus / pathology
  • Hippocampus / physiology
  • Male
  • Memory / physiology*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Nerve Net / cytology
  • Nerve Net / physiology
  • Neurons / cytology
  • Neurons / physiology*
  • Patch-Clamp Techniques
  • Random Allocation
  • Synaptic Potentials / physiology*