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Randomized Controlled Trial
. 2014 Jun;114(6):1321-32.
doi: 10.1007/s00421-014-2866-1. Epub 2014 Mar 16.

Creatine Supplementation Post-Exercise Does Not Enhance Training-Induced Adaptations in Middle to Older Aged Males

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Free PMC article
Randomized Controlled Trial

Creatine Supplementation Post-Exercise Does Not Enhance Training-Induced Adaptations in Middle to Older Aged Males

Matthew B Cooke et al. Eur J Appl Physiol. .
Free PMC article

Abstract

Purpose: The present study evaluated the effects of creatine monohydrate (CrM) consumption post-exercise on body composition and muscle strength in middle to older males following a 12-week resistance training program.

Methods: In a double-blind, randomized trial, 20 males aged between 55 and 70 years were randomly assigned to consume either CrM-carbohydrate (CHO) [20 g days(-1) CrM + 5 g days(-1) CHO × 7 days, then 0.1 g kg(-1) CrM + 5 g CHO on training days (average dosage of ~8.8 g)] or placebo CHO (20 g days(-1) CHO × 7 days, then 5 g CHO on training days) while participating in a high intensity resistance training program [3 sets × 10 repetitions at 75% of 1 repetition maximum (1RM)], 3 days weeks(-1) for 12 weeks. Following the initial 7-day "loading" phase, participants were instructed to ingest their supplement within 60 min post-exercise. Body composition and muscle strength measurements, blood collection and vastus lateralis muscle biopsy were completed at 0, 4, 8 and 12 weeks of the supplement and resistance training program.

Results: A significant time effect was observed for 1RM bench press (p = 0.016), leg press (p = 0.012), body mass (p = 0.03), fat-free mass (p = 0.005) and total myofibrillar protein (p = 0.005). A trend for larger muscle fiber cross-sectional area in the type II fibers compared to type I fibers was observed following the 12-week resistance training (p = 0.08). No supplement interaction effects were observed.

Conclusion: Post-exercise ingestion of creatine monohydrate does not provide greater enhancement of body composition and muscle strength compared to resistance training alone in middle to older males.

Figures

Fig. 1
Fig. 1
Time course of 1RM bench press. Data (mean ± SD) represents 1RM bench press for both CrM-CHO and CHO groups, including the mean average for both groups combined, following 12 weeks of resistance training. Asterisk significantly different from baseline (T1) (p < 0.05). Dagger symbol significantly different from T2 (p < 0.05). Please note that symbols used are a reflection of pairwise analysis for time effects and thus differences between mean averages for both groups combined (mean average line in figure) at each time point
Fig. 2
Fig. 2
Time course of 1RM leg press. Data (mean ± SD) represents 1RM leg press for both CrM-CHO and CHO groups, including the mean average for both groups combined, following 12 weeks of resistance training. Asterisk significantly different from baseline (T1) (p < 0.05). Please note that symbols used are a reflection of pairwise analysis for time effects and thus differences between mean averages for both groups combined (mean average line in figure) at each time point

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References

    1. Antonio J, Ciccone V. The effects of pre versus post workout supplementation of creatine monohydrate on body composition and strength. J Int Soc Sports Nutr. 2013;10(1):36. doi: 10.1186/1550-2783-10-36. - DOI - PMC - PubMed
    1. Bales C, Ritchie C. Sarcopenia, weight loss, and nutritional frailty in the elderly. Annu Rev Nutri. 2002;22:309–323. doi: 10.1146/annurev.nutr.22.010402.102715. - DOI - PubMed
    1. Becque M, Lochman J. Effects of oral creatine supplementation on muscular strength and body composition. Med Sci Sports Exerc. 2000;32(3):654–658. doi: 10.1097/00005768-200003000-00016. - DOI - PubMed
    1. Bemben M, Witten M, Carter J, Eliot K, Knehans A, Bemben D. The effects of supplementation with creatine and protein on muscle strength following a traditional resistance training program in middle-aged and older men. J Nutr Health Aging. 2010;14(2):155–159. doi: 10.1007/s12603-009-0124-8. - DOI - PubMed
    1. Bermon S, Venembre P, Sachet C, Valour S, Dolisi C. Effects of creatine monohydrate ingestion in sedentary and weight-trained older adults. Acta Physiol Scand. 1998;164(2):147–155. doi: 10.1046/j.1365-201X.1998.00427.x. - DOI - PubMed

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