Review collagen-based biomaterials for wound healing

Biopolymers. 2014 Aug;101(8):821-33. doi: 10.1002/bip.22486.


With its wide distribution in soft and hard connective tissues, collagen is the most abundant of animal proteins. In vitro, natural collagen can be formed into highly organized, three-dimensional scaffolds that are intrinsically biocompatible, biodegradable, nontoxic upon exogenous application, and endowed with high tensile strength. These attributes make collagen the material of choice for wound healing and tissue engineering applications. In this article, we review the structure and molecular interactions of collagen in vivo; the recent use of natural collagen in sponges, injectables, films and membranes, dressings, and skin grafts; and the on-going development of synthetic collagen mimetic peptides as pylons to anchor cytoactive agents in wound beds.

Keywords: biocompatible; biodegradable; catgut; extracellular matrix; regenerative medicine.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Bandages
  • Biocompatible Materials / pharmacology*
  • Collagen / pharmacology*
  • Cross-Linking Reagents / pharmacology
  • Humans
  • Peptides / pharmacology
  • Skin / drug effects
  • Wound Healing / drug effects*


  • Biocompatible Materials
  • Cross-Linking Reagents
  • Peptides
  • Collagen