A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

Nature. 1989 Jan 26;337(6205):331-7. doi: 10.1038/337331a0.


The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added template. The essential RNA component of this ribonucleoprotein enzyme has now been cloned and found to contain the sequence CAACCCCAA, which seems to be the template for the synthesis of TTGGGG repeats.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Chromosomes / physiology*
  • Cloning, Molecular
  • DNA / genetics
  • DNA Nucleotidylexotransferase / genetics*
  • Genes
  • Molecular Sequence Data
  • Oligonucleotide Probes
  • RNA / genetics*
  • Repetitive Sequences, Nucleic Acid
  • Tetrahymena / enzymology
  • Tetrahymena / genetics*


  • Oligonucleotide Probes
  • RNA
  • DNA
  • DNA Nucleotidylexotransferase