Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a predictor of conversion from mild cognitive impairment to Alzheimer's disease

J Am Geriatr Soc. 2014 Apr;62(4):679-84. doi: 10.1111/jgs.12742. Epub 2014 Mar 17.


Objectives: To assess the usefulness of the Montreal Cognitive Assessment (MoCA) total score (MoCA-TS) and Memory Index Score (MoCA-MIS) in predicting conversion to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI).

Design: Retrospective chart review.

Setting: Community-based memory clinic.

Participants: Individuals meeting Petersen's MCI criteria (N = 165).

Measurements: Baseline MoCA scores at MCI diagnosis were collected from charts of eligible individuals with MCI, and MoCA-TS, MoCA-MIS, and a cognitive domain index score were calculated to assess their prognostic value in predicting conversion to AD.

Results: One hundred fourteen participants progressed to AD (MCI-AD), and 51 did not (nonconverters; MCI-NC); 90.5% of participants with MCI with a MoCA-TS less than 20/30 and a MoCA-MIS less than 7/15 at baseline converted to AD within the average follow-up period of 18 months, compared with 52.7% of participants with MCI above the cutoffs on both scores. Individuals with multiple-domain amnestic MCI had the highest AD conversion rates (73.9%).

Conclusion: Identifying individuals with MCI at high risk of conversion to AD is important clinically and for selecting appropriate subjects for therapeutic trials. Individuals with MCI with a low MoCA-TS and a low newly devised memory index score (MoCA-MIS) are at greater risk of short-term conversion to AD.

Keywords: Alzheimer; Memory Index Score; Montreal Cognitive Assessment; mild cognitive impairment.

MeSH terms

  • Aged
  • Alzheimer Disease / diagnosis*
  • Alzheimer Disease / epidemiology
  • Alzheimer Disease / psychology
  • Cognition / physiology*
  • Cognitive Dysfunction / diagnosis*
  • Cognitive Dysfunction / epidemiology
  • Cognitive Dysfunction / psychology
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Geriatric Assessment / methods*
  • Humans
  • Incidence
  • Magnetic Resonance Imaging
  • Male
  • Memory / physiology*
  • Neuropsychological Tests
  • Predictive Value of Tests
  • Prognosis
  • Quebec / epidemiology
  • Retrospective Studies
  • Surveys and Questionnaires
  • Tomography, X-Ray Computed