Bioactive metabolites from the mycelia of the basidiomycete Hericium erinaceum

Nat Prod Res. 2014;28(16):1288-92. doi: 10.1080/14786419.2014.898145. Epub 2014 Mar 18.

Abstract

Seven known compounds, three diketopiperazine alkaloids, 12β-hydroxyverruculogen TR-2 (1), fumitremorgin C (2) and methylthiogliotoxin (5), two hetero-spirocyclic γ-lactam alkaloids, pseurotin A (3) and FD-838 (4), and cerevisterol (6) and herierin IV (7), were isolated from the mycelia of the basidiomycete Hericium erinaceum and identified by spectroscopic analyses. The antioxidant and antifungal activities of compounds 1-6 were evaluated. The results indicated that compounds 1, 3 and 6 exhibited potential antioxidant activity against DPPH (2, 2-diphenyl-1-picrylhydrazyl) radical with their IC50 data of ca. 12 μM, compared with positive control tertiary butylhydroquinone. In addition, compound 4 significantly inhibited the growth of two plant fungal pathogens Botrytis cinerea and Glomerella cingulata with an minimum inhibitory concentration of 6.25 μM for each, similar to that of the positive fungicide, carbendazim. Compounds 1-5 were isolated from the genus Hericium for the first time.

Keywords: Hericium erinaceum; antifungal activity; antioxidant activity; diketopiperazine alkaloids; mushroom.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology*
  • Antioxidants / chemistry
  • Antioxidants / isolation & purification*
  • Antioxidants / pharmacology*
  • Basidiomycota / chemistry*
  • Biphenyl Compounds / pharmacology
  • China
  • Diketopiperazines / chemistry
  • Diketopiperazines / isolation & purification
  • Diketopiperazines / pharmacology
  • Furans / chemistry
  • Furans / isolation & purification
  • Furans / pharmacology
  • Imidazoles / chemistry
  • Imidazoles / isolation & purification
  • Imidazoles / pharmacology
  • Inhibitory Concentration 50
  • Molecular Structure
  • Mycelium / chemistry
  • Nuclear Magnetic Resonance, Biomolecular
  • Picrates / pharmacology

Substances

  • Antifungal Agents
  • Antioxidants
  • Biphenyl Compounds
  • Diketopiperazines
  • FD 838
  • Furans
  • Imidazoles
  • Picrates
  • 1,1-diphenyl-2-picrylhydrazyl