Should linking replace regression when mapping from profile-based measures to preference-based measures?

Value Health. 2014 Mar;17(2):261-5. doi: 10.1016/j.jval.2013.12.002.


Background: Profile instruments are frequently used to assess health-related quality of life and other patient-reported outcomes. However, preference-based measures are required for health-economic cost-utility evaluations.

Results: Although regression-based approaches are commonly used to map from profile measures to preference measures, we show that this results in biased estimates because of regression to the mean.

Conclusions: Linking (scale-aligning) is proposed as an alternative.

Keywords: linking values; mapping functions; patient-reported outcomes; preference-based measures; profile instruments; scale-aligning; test equating.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Clinical Trials as Topic / methods
  • Cost-Benefit Analysis
  • Humans
  • Observational Studies as Topic / methods
  • Outcome Assessment, Health Care / methods*
  • Quality of Life*
  • Regression Analysis
  • Research Design*
  • Self Report