Whipple's disease in a patient with longstanding seronegative polyarthritis

Scand J Rheumatol. 1988;17(5):423-6. doi: 10.3109/03009748809105282.


We describe a middle-aged woman with Whipple's disease. She suffered from a seronegative rheumatoid-like polyarthritis for more than 20 years before the diagnosis of Whipple's disease was made. This case shows that arthritis may be a feature of occult Whipple's disease. Without gastrointestinal symptoms, diagnosis is very difficult. Diagnosis is important because treatment can rapidly improve this life-threatening disease.

Publication types

  • Case Reports

MeSH terms

  • Arthritis / complications*
  • Arthritis / immunology
  • Biopsy
  • Female
  • Humans
  • Jejunum / ultrastructure
  • Middle Aged
  • Serologic Tests
  • Whipple Disease / complications*
  • Whipple Disease / pathology