Insights into the biological functions of Dock family guanine nucleotide exchange factors

Genes Dev. 2014 Mar 15;28(6):533-47. doi: 10.1101/gad.236349.113.


Rho GTPases play key regulatory roles in many aspects of embryonic development, regulating processes such as differentiation, proliferation, morphogenesis, and migration. Two families of guanine nucleotide exchange factors (GEFs) found in metazoans, Dbl and Dock, are responsible for the spatiotemporal activation of Rac and Cdc42 proteins and their downstream signaling pathways. This review focuses on the emerging roles of the mammalian DOCK family in development and disease. We also discuss, when possible, how recent discoveries concerning the biological functions of these GEFs might be exploited for the development of novel therapeutic strategies.

Keywords: Dock180; Elmo; migration; mouse models; myoblast fusion; neurogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disease / genetics*
  • Enzyme Activation
  • Growth and Development / genetics*
  • Guanine Nucleotide Exchange Factors / genetics
  • Guanine Nucleotide Exchange Factors / metabolism*
  • Humans
  • Neurogenesis / genetics
  • Signal Transduction / genetics
  • rho GTP-Binding Proteins / genetics
  • rho GTP-Binding Proteins / metabolism


  • Guanine Nucleotide Exchange Factors
  • rho GTP-Binding Proteins