BTB-ZF transcription factors, a growing family of regulators of early and late B-cell development

Immunol Cell Biol. 2014 Jul;92(6):481-8. doi: 10.1038/icb.2014.20. Epub 2014 Mar 18.


The differentiation of early B-cell precursors in the bone marrow into the variety of mature and effector B-cell subsets of the periphery is a complex process that requires tight regulation at the transcriptional level. Different members of the broad complex, tramtrack, bric-à-brac and zinc finger (BTB-ZF) family of transcription factors have recently been shown to have key roles in many phases of B-cell development, including early B-cell development in the bone marrow, peripheral B-cell maturation and specialization into effector cells during an immune response. This review highlights the critical functions mediated by BTB-ZF transcription factors within the B-cell lineage and emphasizes how the deregulation of these transcription factors can lead to B-cell malignancies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / cytology
  • B-Lymphocytes / immunology*
  • Bone Marrow / immunology
  • Hematologic Neoplasms / genetics
  • Hematologic Neoplasms / immunology
  • Humans
  • Transcription Factors / genetics
  • Transcription Factors / immunology*
  • Zinc Fingers / genetics
  • Zinc Fingers / immunology*


  • Transcription Factors