Neural map formation in the mouse olfactory system

Cell Mol Life Sci. 2014 Aug;71(16):3049-57. doi: 10.1007/s00018-014-1597-0. Epub 2014 Mar 18.

Abstract

In the mouse olfactory system, odorants are detected by ~1,000 different odorant receptors (ORs) produced by olfactory sensory neurons (OSNs). Each OSN expresses only one functional OR species, which is referred to as the "one neuron-one receptor" rule. Furthermore, OSN axons bearing the same OR converge to a specific projection site in the olfactory bulb (OB) forming a glomerular structure, i.e., the "one glomerulus-one receptor" rule. Based on these basic rules, binding signals of odorants detected by OSNs are converted to topographic information of activated glomeruli in the OB. During development, the glomerular map is formed by the combination of two genetically programmed processes: one is OR-independent projection along the dorsal-ventral axis, and the other is OR-dependent projection along the anterior-posterior axis. The map is further refined in an activity-dependent manner during the neonatal period. Here, we summarize recent progress of neural map formation in the mouse olfactory system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Axons / metabolism
  • Cyclic AMP / metabolism
  • Gene Expression Regulation, Developmental
  • Mice
  • Models, Molecular
  • Olfactory Pathways / cytology
  • Olfactory Pathways / embryology*
  • Olfactory Pathways / metabolism*
  • Olfactory Receptor Neurons / cytology
  • Olfactory Receptor Neurons / embryology*
  • Olfactory Receptor Neurons / metabolism*
  • Receptors, G-Protein-Coupled / metabolism
  • Receptors, Odorant / metabolism*

Substances

  • Receptors, G-Protein-Coupled
  • Receptors, Odorant
  • Cyclic AMP