Emergency treatment of status asthmaticus with enoximone

Br J Anaesth. 2014 Jun;112(6):1105-8. doi: 10.1093/bja/aeu048. Epub 2014 Mar 17.


This report describes the treatment of eight patients with status asthmaticus, six of whom were already maximally treated. They were consequently treated with enoximone, a selective phosphodiesterase III inhibitor, in their refractory phase. Bronchodilatation in these patients was immediate. No side-effects were observed. Enoximone appears to be a valuable addition to the treatment of status asthmaticus. I.V. administration bypasses inhalation incapability in severe asthma. It is likely to reduce or altogether prevent the need for resorting to secondary or tertiary high-tech therapy such as mechanical ventilation or anaesthetics, thus avoiding complications, as well as for transfers to specialized intensive care units. Not only do these aspects enable substantial cost savings, but they also may spare the patient a lot of anguish and a prolonged recovery.

Keywords: asthma; enoximone; intensive care; respiratory factors.

MeSH terms

  • Administration, Intravenous
  • Adolescent
  • Adult
  • Aged
  • Emergency Treatment / methods*
  • Enoximone / administration & dosage*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Phosphodiesterase 3 Inhibitors / administration & dosage*
  • Status Asthmaticus / drug therapy*
  • Treatment Outcome


  • Phosphodiesterase 3 Inhibitors
  • Enoximone