History of the molecular biology of cytomegaloviruses

Methods Mol Biol. 2014;1119:1-14. doi: 10.1007/978-1-62703-788-4_1.


The history of the molecular biology of cytomegaloviruses from the purification of the virus and the viral DNA to the cloning and expression of the viral genes is reviewed. A key genetic element of cytomegalovirus (the CMV promoter) contributed to our understanding of eukaryotic cell molecular biology and to the development of lifesaving therapeutic proteins. The study of the molecular biology of cytomegaloviruses also contributed to the development of antivirals to control the viral infection.

Publication types

  • Historical Article

MeSH terms

  • Cloning, Molecular
  • Cytomegalovirus / genetics*
  • Cytomegalovirus / pathogenicity
  • Cytomegalovirus Infections / genetics
  • Cytomegalovirus Infections / virology*
  • DNA, Viral / genetics*
  • Gene Expression Regulation, Viral
  • History, 20th Century
  • Molecular Biology / history
  • Molecular Biology / methods*
  • Promoter Regions, Genetic


  • DNA, Viral