Angiosarcoma successfully treated with liver transplantation and sirolimus

Pediatr Transplant. 2014 Jun;18(4):E114-9. doi: 10.1111/petr.12245. Epub 2014 Mar 19.


Malignant liver tumors represent approximately 1% of malignancies in children. HA is a high-grade tumor of endothelial cells that is even more rare in the pediatric population. HA has a limited response to chemotherapy, radiation and resection with universal tumor recurrence with LT and nearly 100% mortality by 18 months. This is the first reported successful case of hepatic angiosarcoma in a child who was treated by LT in combination with sirolimus. Sirolimus antagonizes the mTOR pathway, which regulates cell proliferation, differentiation, and migration, and is being studied as an anti-neoplastic agent for solid tumors.

Keywords: child; liver transplantation; malignancy; pediatric liver transplantation; sirolimus.

Publication types

  • Case Reports

MeSH terms

  • Antibiotics, Antineoplastic / therapeutic use*
  • Chemotherapy, Adjuvant
  • Child, Preschool
  • Female
  • Hemangiosarcoma / drug therapy*
  • Hemangiosarcoma / surgery
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Liver Neoplasms / drug therapy*
  • Liver Neoplasms / surgery
  • Liver Transplantation*
  • Sirolimus / therapeutic use*


  • Antibiotics, Antineoplastic
  • Immunosuppressive Agents
  • Sirolimus