Enantiomers of clofibric acid analogs have opposite actions on rat skeletal muscle chloride channels

Pflugers Arch. 1988 Nov;413(1):105-7. doi: 10.1007/BF00581238.


The S-(-) isomers of a series of clofibric acid analogs produced only a block of chloride conductance of rat skeletal muscle fibers with increasing concentrations until block was nearly complete. The R-(+) isomers, on the other hand, at low concentrations increased chloride conductance by as much as 9% to 39% and at higher concentrations decreased chloride conductance, but never by more than 27% of the control value. The actions of the enantiomeric pairs to either produce or inhibit myotonic excitability paralleled their ability to block or increase chloride conductance, respectively.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chlorides / metabolism*
  • Clofibrate / analogs & derivatives*
  • Clofibric Acid / analogs & derivatives
  • Clofibric Acid / pharmacology*
  • In Vitro Techniques
  • Ion Channels / drug effects*
  • Male
  • Muscles / drug effects*
  • Muscles / metabolism
  • Rats
  • Rats, Inbred Strains
  • Stereoisomerism


  • Chlorides
  • Ion Channels
  • Clofibric Acid
  • Clofibrate