Assessment of efficacy of platelet-rich plasma (PRP) on infraorbital dark circles and crow's feet wrinkles

J Cosmet Dermatol. 2014 Mar;13(1):72-8. doi: 10.1111/jocd.12072.


Background: Infraorbital skin hyperpigmentation, commonly called dark circles, and crow's feet wrinkles are common cosmetic concerns. Various methods of treatment have been evaluated with variable outcomes.

Objective: This study was performed to assess the efficacy of platelet-rich plasma (PRP) injection for treating periorbital dark circles and crow's feet.

Methods: Ten participants with a mean age of 41.2 years were treated in a single session with intradermal injections of 1.5 mL PRP into tear trough area and crow's feet wrinkles on each side. The effects on melanin content, color homogeneity of the treated area, epidermal stratum corneum hydration, and wrinkle volume and visibility index were compared 3 months after treatment with baseline. Physician's global assessment and participants' satisfaction and any potential side effects were also assessed.

Results: The improvement in infraorbital color homogeneity was statistically significant (P = 0.010), but no statistically significant changes were observed in melanin content, stratum corneum hydration, wrinkle volume, and visibility index. Participant's satisfaction score and physician's global assessment score were 2.2 and 1.7, respectively, on a 0-3 scale.

Conclusion: Platelet-rich plasma may have the potential to improve infraorbital dark circle in terms of color homogeneity of the region, though this remains to be proven using larger, controlled studies using multiple injections.

Keywords: crow's feet; melanin; platelet-rich plasma; trial; wrinkles.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Dermatologic Agents*
  • Esthetics
  • Eyelids
  • Humans
  • Injections, Intradermal
  • Middle Aged
  • Patient Satisfaction
  • Platelet-Rich Plasma*
  • Skin Aging*
  • Skin Pigmentation / drug effects


  • Dermatologic Agents