VE-cadherin at a glance

Cell Tissue Res. 2014 Mar;355(3):515-22. doi: 10.1007/s00441-014-1843-7. Epub 2014 Mar 20.


Although being a monolayer the vascular endothelium controls fundamental vessel functions such as permeability, leukocyte extravasation and angiogenesis. The endothelial selective transmembrane constituent of adherens junctions, Vascular Endothelial- (VE-) cadherin plays a crucial role in the regulation of such activities. The signaling pathways controlled by VE-cadherin as well as the ones that regulate VE-cadherin activity start to be elucidated. This delineates a complex network of molecular and functional interactions that can be altered in pathologies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, CD / chemistry
  • Antigens, CD / physiology*
  • Cadherins / chemistry
  • Cadherins / physiology*
  • Humans


  • Antigens, CD
  • Cadherins
  • cadherin 5