Transient postnatal elevation of serotonin levels in mouse neocortex

Brain Res. 1988 Sep 1;471(1):163-6. doi: 10.1016/0165-3806(88)90163-0.


Serotonin (5-HT), norepinephrine (NE) and 5-hydroxyindoleacetic acid (HIAA) levels were measured during ontogeny of frontoparietal cortex in Balb/C mice by high-pressure liquid chromatography (HPLC) with electrochemical detection. Unlike NE, the concentration of 5-HT was transiently elevated to more than twice the adult level during the first postnatal week; this was accompanied by increased HIAA content comparable to the adult, indicating elevated levels of 5-HT release. Since a transient hyperplasia of 5-HT-immunoreactive fibers and uptake sites has been observed previously in the same cortical areas, the transient elevation of 5-HT levels may play an important role in shaping early postnatal morphogenetic events in neocortex.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aging
  • Animals
  • Animals, Newborn
  • Cerebral Cortex / growth & development*
  • Cerebral Cortex / metabolism
  • Hydroxyindoleacetic Acid / metabolism
  • Mice
  • Mice, Inbred BALB C
  • Norepinephrine / metabolism
  • Serotonin / metabolism*


  • Serotonin
  • Hydroxyindoleacetic Acid
  • Norepinephrine