Simple lifestyle recommendations and the outcomes of gestational diabetes. A 2 × 2 factorial randomized trial

Diabetes Obes Metab. 2014 Oct;16(10):1032-5. doi: 10.1111/dom.12289. Epub 2014 Apr 7.


The benefits of exercise and behavioural recommendations in gestational diabetes mellitus (GDM) are controversial. In a randomized trial with a 2 × 2 factorial design, we examined the effect of exercise and behavioural recommendations on metabolic variables, and maternal/neonatal outcomes in 200 GDM patients. All women were given the same diet: group D received dietary recommendations only; group E was advised to briskly walk 20-min/day; group B received behavioural dietary recommendations; group BE was prescribed the same as B + E. Dietary habits improved in all groups. In a multivariable regression model, fasting glucose did not change. Exercise, but not behavioural recommendations, was associated with the reduction of postprandial glucose (p < 0001), glycated haemoglobin (HbA1c; p < 0.001), triglycerides (p = 0.02) and C-reactive protein (CRP; p < 0.001) and reduced any maternal/neonatal complications (OR = 0.50; 95%CI=0.28-0.89;p = 0.02). In GDM patients a simple exercise programme reduced maternal postprandial glucose, HbA1c, CRP, triglycerides and any maternal/neonatal complications, but not fasting glucose values.

Keywords: behavioural recommendations; exercise; gestational diabetes mellitus.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Birth Weight
  • Diabetes, Gestational / prevention & control*
  • Diet*
  • Directive Counseling
  • Exercise*
  • Female
  • Health Behavior*
  • Humans
  • Life Style*
  • Patient Compliance / statistics & numerical data*
  • Pregnancy