SUMMARY Over the past two decades increasingly compelling research has identified pain catastrophizing as an important psychological risk factor for a wide range of pain-related outcomes. In response to this literature, there have been calls for the clinical use of catastrophizing as a prognostic indicator of problematic recovery, and for the development of clinical interventions that target catastrophizing and its correlates. This article provides a review of the evidence-based assessment and management tools that are available for the clinical management of patients with elevated levels of catastrophic thinking. Recent research and clinical implementation strategies are discussed for the following interventions: cognitive behavioral techniques, emotional disclosure, reassurance and activity encouragement, neurophysiological education, and graded activity and exposure.