Lipid-lowering and antioxidant functions of bottle gourd (Lagenaria siceraria) extract in human dyslipidemia

J Evid Based Complementary Altern Med. 2014 Apr;19(2):112-8. doi: 10.1177/2156587214524229. Epub 2014 Feb 20.


The study validated the antidyslipidemic, antioxidant, and antihyperglycemic effects of Lagenaria siceraria fruit extract in human subjects with dyslipidemia along with subjects of normal health. A total of 200 mL of freshly prepared Lagenaria siceraria fruit extract was administered daily on empty stomach for 90 days. Significant reductions (P < .01) were found in triglycerides and total cholesterol levels in blood. Cardiac risk ratio, atherogenic coefficient, and atherogenicity index of plasma were also improved. Appreciable reductions in body mass index (P < .01) and blood pressure (systolic P < .01, diastolic P < .05) along with a significant reduction (P < .05) in fasting blood glucose levels were also observed in these subjects. Lagenaria siceraria fruit extract exhibited significant antioxidant activity in dyslipidemic subjects as evident from elevations in SOD (P < .05) and GSH levels (P < .01) with marked improvement in catalase (P < .01) and TBARS levels (P < .05). Phytochemical screening confirmed the presence of saponins, glycosides, flavonoids, terpenoids, and phenolic compounds. Lagenaria siceraria fruit extract serves as dietary adjunct in treatment of human dyslipidemia and cardiovascular disease.

Keywords: Lagenaria siceraria; atherosclerosis; dyslipidemia; hyperglycemia; oxidative stress.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antioxidants / therapeutic use*
  • Blood Glucose / drug effects
  • Blood Pressure / drug effects
  • Body Weight / drug effects
  • Case-Control Studies
  • Cucurbitaceae / chemistry*
  • Dyslipidemias / blood
  • Dyslipidemias / drug therapy*
  • Humans
  • Hypolipidemic Agents / therapeutic use*
  • Lipid Metabolism / drug effects
  • Lipids / blood
  • Middle Aged
  • Oxidative Stress / drug effects
  • Plant Extracts / chemistry
  • Plant Extracts / therapeutic use*
  • Seeds / chemistry


  • Antioxidants
  • Blood Glucose
  • Hypolipidemic Agents
  • Lipids
  • Plant Extracts