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. 2014 Mar;75(2):76-87.
doi: 10.1002/ddr.21157. Epub 2013 Nov 15.

Synthesis and antimetastatic effects of E-salignone amide derivatives

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Synthesis and antimetastatic effects of E-salignone amide derivatives

Hong-Ling Wang et al. Drug Dev Res. 2014 Mar.

Abstract

The preparation of novel E-salignone derivatives and their biological evaluation as potential antimetastatic agents is described. The E-salignone amide derivatives were prepared from epiandrosterone and androsterone, and characterized by analytical (1) H NMR, (13) C NMR, and mass spectrometry. The derivatives were evaluated for antimetastatic activity in MDA-MB-231 cells by using a transwell assay. Comparing with the positive control, LY294002, compounds 19b, 19d, and 19e exhibited significant inhibitory effects on the EGF-induced invasion of MB-MDA-231 cells. Moreover, compound 19b also had antimigration effects in wound-healing assay. Compound 19b may represent a novel antimetastatic agent for treating breast cancer.

Keywords: E-salignone; amide derivatives; antimetastasis; breast cancer cells.

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