Untangling GABAergic wiring in the cortical microcircuit

Curr Opin Neurobiol. 2014 Jun:26:7-14. doi: 10.1016/j.conb.2013.10.003. Epub 2013 Nov 16.


The cerebral cortical microcircuit is composed of pyramidal and non-pyramidal cells and subcortical and cortico-cortical afferents. These constitute a complex wiring structure that remains poorly understood. At least ten non-pyramidal cell subtypes are known. These innervate different target neuronal domains, and have a key role in regulating cortical neuronal activity. Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the cerebral cortex, and most cortical inhibitory synapses originate from non-pyramidal cells. Therefore, investigating the morphological and functional wiring properties of GABAergic non-pyramidal cells is critical to understanding the functional architecture of the cortical microcircuitry. This review focuses on current understanding of the different roles of inhibitory GABAergic non-pyramidal cell subtypes in cortical functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Action Potentials / physiology
  • Animals
  • Cerebral Cortex / anatomy & histology*
  • Humans
  • Nerve Net / cytology*
  • Neural Inhibition / physiology*
  • Neurons / classification
  • Neurons / physiology*
  • gamma-Aminobutyric Acid / metabolism*


  • gamma-Aminobutyric Acid